7 Seeds 04 Vf
Founded in 1856, all Ferry-Morse seeds are Non-GMO. We pride ourselves on our seed freshness... Ferry-Morse pioneered the practice of selling only fresh flower, herb and vegetable seeds, packed for the current season. Fresh seed means better germination rates. Always check for freshness by looking for the date on the back of the packet.
7 Seeds 04 vf
Traditional heirloom canning tomatoes earned their reputation by providing fewer seeds, meaty flesh, and thick skins, all prime traits for tomatoes that home cooks would peel in a hot water bath before canning.
One species with a potential antifungal activity is Coriandrum sativum L., popularly known as coriander. It is a small annual plant belonging to the Apiaceae family in the order of Apiales which originating from the Eastern Mediterranean where its use dates back to around 1,550 BC [10]. Coriander leaves and seeds are widely used in folk medicine as a cholesterol-lowering agent, a digestive stimulant, and an anti-hypertensive agent [11], in addition to its use as a seasoning in food preparation. Pharmaceutical applications of C. sativum have also revealed antibacterial [12], antioxidant [13], hepatoprotective [14] and anticonvulsant [15] activities.
The EO from C. sativum has been proven to have a strong antifungal effect against Candida species [9], [16], [17]. However, most studies have analyzed the EO from fruits [17] and seeds [9], which have a different chemical composition from those present in the leaves [16], [18]. Considering that C. sativum warrants further investigation, e.g. for the treatment of denture-related oral candidiasis, there is a need to elucidate the antifungal activity of the EO from its leaves with regard to mode of action, activity against Candida biofilms, and to perform pharmacogenomic analyses for toxicological purposes.
Although it has a rather different chemical composition, the EO from C. sativum seeds also has antimicrobial activity, whose primary mode of action is cell permeabilization and consequent DNA leakage in yeasts [9] and bacteria [44] based on flow cytometry analyses.
C. sativum is approved for food uses by the Food and Drug Administration, which granted it the GRAS (Generally Regarded as Safe) status, and also by the Council of Europe (CoE) [58]. Based on the history of consumption of C. sativum leaves without reported adverse effects, and lack of toxicity of the major constituent from the seeds EO (linalool) [9], the use of C. sativum as an additional food ingredient is considered safe [60]. The median lethal dose (LD50) of C. sativum seeds EO was determined as 2.257 ml/kg [61]. Nevertheless, the LD50 of the leaves EO has not been reported in the literature and remains unclear, as chemical composition of the EO from the leaves differs substantially from that of the seeds.
Cross-seeding of Aβ42 amyloid self-assembly by fIAPP accelerates Aβ42 amyloid self-assembly and could link the onset and pathogenesis of T2D with AD8,11,14. In a simplified mechanistic scenario, fIAPP seeds will template the formation of IAPP/Aβ42 hetero-amyloids, which will template further cytotoxic Aβ42 self-/cross-assembly events1,13. Thereby, polymorphic cross-interactions between amyloid core regions may play an important role24,25,26,27,28,29.